Bio-physical interaction mechanisms and bio-electronic interfaces

TIPS

TIPS for Innovative Technology For Health (Technologies Innovantes Pour la Santé) explores the properties and applications of the living-electronic interface, in order to better understand certain mechanisms of biophysical interaction or to propose new therapeutic devices. It is based on the establishment of a bidirectional communication between biological tissues and electronic circuits, in vitro or in vivo, in the direction of the acquisition of bio-signals or that of electrical stimulation.

Presentation of the bioeletronic research activities of the TIPS team

The TIPS teams address Health Technologies by focusing on the bioelectronics interface (recording and stimulation) but also biological signal processing and biomimetic artificial systems. Several fields of exploration then opened up involving neuronal, muscular tissues, pancreatic or cardiac cells. The TIPS team made the strategic choice to design real-time acquisition, biomimetic signal and stimulation instruments, configurable and multi-application, which are constantly enriched (programming functionalities, real-time, HMI, etc.) over the course of our collaborations and needs.

2 modular Instruments for living-artificial hybridization

MULTIMED :

Instrument for in vitro biomedical signal acquisition and real-time processing and for conducting closed-loop experiments. MULTIMED is used in 6 projects and by 5 partners.

TWIST :

Electrical stimulator capable of delivering arbitrary waveforms produced in real time on tissues or cells in vitro or in vivo, and which also allows the measurement of bioimpedance. TWIST is used in 3 projects and by 5 partners, and its development is at the heart of the SMARTSTIM inter-laboratory team that we have been coordinating since 2018.

This strategy of designing, monitoring and distributing multi-application (and open access) resources, allows us both to explore new concepts of hybridization of living-artificial computing, to verify application-specific configurations and improve our impact in our community.

Societal challenge

improvement of patient well-being, disability compensation

Fields of study / application

Neuroprosthetics, neurodegenerative diseases, diabetology, cardiac system, bioimpedancemetry

Scientific objectives

– The study of bio-physical interaction mechanisms

– Modeling and emulation in silico, in vitro and organ on chip

– The innovation of the bioelectronics interface itself, new biosensors design

– The development of new bio-electrical analysis tools

– The design of new electroceutical devices

– Conception of real-time closed loop systems for Health applied to different biological cells and tissues

Tools / development

Configurable circuits and systems, neuromimetic circuits, embedded electrophysiology, microfluidics, microelectrode arrays

TIPS teams skills

Modeling of the Electronic/Living Interface

Real-time embedded computing

Spiking Neural Network (SNN) modeling and hardware implementation

The circuits and systems developed are tested in the context of in vitro or in vivo experiments

Recording, stimulation, biomarker extraction

Analog and mixed integrated circuits

Organ-on-chip

Partners

Collaborations and partners

For the various research projects underway, the IMS Bordeaux laboratory and its teams rely on strong partnerships and collaborations, which allow for the creation of a synergy of strengths and a sharing of technical and human resources