This thesis investigates the fabrication and characterization of OECTs for biological applications. Microfabricated devices functionalized by electropolymerizing various monomers enabled the development of high-performance PEDOT-based OECTs (gm,max ~12 mS) that remained stable in biological media and were tested with HL-1 cells. A zinc-selective trimer (Tri-DPA) was used to create sensitive Zn²⁺ sensors (LoD ~1.5 µM) for monitoring β-cell secretion. Additionally, electropolymerization of an n-type NDI-thiophene monomer initiated the development of n-type OECTs for future complementary circuits. Overall, this work advances OECT-based sensors for electrophysiology and ion detection.
