Today, cardiac diseases are the world’s leading cause of death, and their prevalence will continue to rise in the coming years due to changing lifestyles and demographics. Some of these diseases affect the heartbeat generation mechanism involving the axis between the nervous system and cardiac system.
During this thesis, a system to study this axis and lay the foundation for a therapeutic solution was developed. This platform can reproduce the mechanisms involved in a healthy heartbeat by mimicking its behavior at a cellular level in real-time. This method allows inserting the platform into an environment where its inputs and outputs can be biological or artificial. Thus, it can be used in various environments to investigate these diseases and lead to the development of therapeutic solutions. Tests were conducted by interfacing with neural networks to reproduce the nervous system and in vitro cardiomyocyte culture to act as cardiac part.
