For competitive positioning, manufacturing companies are leveraging two key paradigms: Lean for organizational efficiency in production and Industry 4.0 (I4.0) for technological transformation. The objective of this thesis is to explore potential synergies between Lean practices (LP) and the technologies of I4.0 through a comprehensive global model of interaction analysis. This conjoint model is developed based on an extensive literature review and empirical evidence gathered from a survey sent to 200 manufacturing industrialists. The model aims to analyze specific requirements, such as industrial objectives, to define the most effective pathways joining LP and I4.0 for achieving desired outcomes. The integrative model, formalized by a supporting algorithm called LeaTechRP (Lean Practices and Technologies of I4.0 Research Path), aligns with the company’s goals and provides diverse combinations for implementation.